Diabetes

New and promising research has shown improvement in microcirculatory disorders experienced by diabetic patients that were treated with Daflon 500mg—a fraction flavonoid, 90% of which is comprised of the supplement Diosmin.

Elevated blood sugar associated with diabetes places immense stress on the blood vessels, which filter the blood and form urine. As a result, the filtration process is hindered, causing the body to retain waste and fluids, while leaking essential particles, like the protein albumin, into the urine. High albumin levels in the urine of diabetics indicate the presence of kidney disease and fluid retention, called oedema.

A study conducted in France by a research team led by A. Behar, M.D., treated thirteen diabetic outpatients who had been suffering from a microcirculatory condition anywhere from one to nineteen years and who had abnormal albumin retention. Each study participant took two tablets daily of Daflon 500 mg for the duration of one month. Any treatments that were already in place prior to participation were continued during the study. A test was performed before and at the end of the study to measure albumin retention in the urine. Twelve of the thirteen patients experienced normalization in the levels of albumin. In 10 out of 13 patients, the test was carried out a third time several months after the Daflon 500mg treatment was withdrawn. For patients who had albumin normalization during treatment, results were again abnormal.†

In a different study, also conducted by Behar, a placebo-controlled trial lasting 30 to 42 days included two equal groups of 20 diabetic patients—one group treated with the flavonoid fraction and one being a placebo group. At the end of treatment, albumin retention significantly decreased in the group treated with the flavonoid fraction in contrast with the placebo group. In 65% of the flavonoid patients, albumin levels normalized, compared to only 25% of patients in the placebo group. This study, along with others testing the flavonoid fraction Daflon 500mg, suggest that this treatment can improve and even normalize capillary filtration of albumin in diabetic patients.††

†Behar A, Valensi P, de Champvallins M, Cohen-Boulakia F, Albagli B. Capillary filtration and lymphatic resorption in diabetes. Application to the pharmacodynamic activity of Daflon 500 mg. Int. Angiol. 1989; 8(4): 27-29.

††Valensi PE, Behar A, de Chamsvallins MM, Attalah M, Boukalia FC, Attali JR. Effects of a purified flavonoid fraction on capillary filtration in diabetic patients. Diabet. Med. 1996; 13(10): 882-888.